| abstract |
The invention discloses a preparation method of α-murocholic acid. The method uses 3α, 6α, 7α trihydroxy-5β-cholanoic acid (porcine cholic acid) as a starting material, and the process comprises: esterification of carboxyl groups, 3-position, Acetylation of the 7-hydroxyl group, oxidation of the 6-position hydroxyl group, reduction of the 6-position carbonyl group, hydrolysis and recrystallization to obtain high-purity 3α, 6β, 7α-trihydroxy-5β-cholanoic acid, namely α-murocholic acid. The α-murocholic acid synthesized and prepared by the above-mentioned route in the present invention has a wide range of raw material sources; and has high yield, high purity and few side reactions, and is suitable for mass preparation. |