Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0e19f4be0158b0f34a8865653cb54fc4 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H15-203 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-203 |
filingDate |
2021-04-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c303f78a0c4b1423c3fbc959c6b3925d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ffc553f45b7236fa3a33e705dea4d572 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c506b7882117015ac329b59dc607128a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c13dde81e31a4cb11cf7265dcfffb237 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8d8338c38cf20487ed91d32f453bd9c2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d1f9603692167ba81307072a4b511ea8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e0329536b239db6bdf93ed20b651fa0d |
publicationDate |
2021-09-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
CN-113336809-A |
titleOfInvention |
Specific inhibitor of cytochrome P45046A 1 enzyme and application thereof |
abstract |
The invention aims to provide a specific inhibitor of cytochrome P450(CYP)46A1 and application thereof, which can be used for phenotype research of CYP46A1, including identification of whether CYP46A1 participates in the metabolic reaction of specific endogenous steroids and the contribution rate thereof. The IC of the compound for inhibiting CYP46A1 enzyme is found by in vitro activity assay 50 Values around 26 nanomolar, but IC for other CYP subtypes 50 Values greater than 100 micromolar have significant selectivity of inhibition. Suggesting such combinationThe compound has good application prospect in the research of cytochrome P450 metabolism and the application of identifying the contribution rate of CYP46A1 participating in the metabolism of endogenous steroids. |
priorityDate |
2021-04-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |