http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113336791-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_90019bfff9f76dd2bf4374d2c74d639e |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2229-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2229-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2229-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-584 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C209-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-65502 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J29-48 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C211-27 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-655 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J29-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C209-00 |
| filingDate | 2021-05-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_09baf1c201fb8adbe96c1a0cbdf34b16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_018f4082e3ffe75f2b6e34142f5b8f8d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7e8b85b18973cf010459e25736d85fec |
| publicationDate | 2021-09-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113336791-A |
| titleOfInvention | Production method of fosfomycin calcium bulk drug |
| abstract | The invention discloses a method for producing a fosfomycin calcium raw material drug, which comprises the steps of adding a resolving reagent phenylethylamine into a reaction solution of cis-form propylene phosphonic acid to form a racemate, then adding an oxidizing reagent to form epoxypropenephosphonic acid, wherein the epoxidation of cis-propenephosphonic acid to generate a racemic mixture is a key step of the whole synthesis reaction, the addition of the catalyst can enable the cis-propenephosphonic acid to realize epoxidation at a lower temperature, the addition of the ZSM-5 molecular sieve serves as a catalyst carrier to enable the catalyst to keep a good crystal structure, sodium tungstate and sodium molybdate are well dispersed in the pore channel of the ZSM-5 molecular sieve, so that the influence of the mixture of the catalyst and a product on the purity of the product is avoided, the catalyst is effectively recovered and recycled, the method is more environment-friendly and economical, and the yield of the fosfomycin calcium raw material medicine prepared by the production method reaches 49.6-51.2%. |
| priorityDate | 2021-05-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 55.