http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113336701-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K2211-1029 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2021-6432 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2021-6439 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D221-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-6428 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C09K11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N21-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D221-06 |
| filingDate | 2021-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113336701-B |
| titleOfInvention | Nitric oxide two-photon lipid droplet locking fluorescent probe, preparation method thereof and application thereof in detecting neuroinflammation |
| abstract | The invention discloses a nitric oxide two-photon lipid droplet locking fluorescent probe, a preparation method thereof and application thereof in detecting neuroinflammation. The two-photon fluorescent probe (SUN-TAN) is a compound with a structure shown in a formula I. In the two-photon probe, the aromatic secondary amine is used as the NO recognition domain, so that the interference of other active oxygen substances when the o-phenylenediamine is used as the NO recognition domain can be avoided, and the selectivity of the probe can be improved; the modified polyethylene glycol chain structure (amino triethylene glycol monomethyl ether) can increase the solubility of the probe and improve the biocompatibility of the probe in vivo, and is favorable for crossing a blood brain barrier to enter deep brain tissue; meanwhile, the triphenylamine structure is used as a lipid drop positioning group, so that targeted positioning to a neuroinflammation part is facilitated, and the detection accuracy is improved; and the naphthalimide structural unit is used as a fluorescent group, so that the naphthalimide structural unit has the advantages of high stability and high quantum yield, and is favorable for obtaining clearer imaging results. |
| priorityDate | 2021-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 156.