| abstract |
The invention belongs to the field of medicine, and particularly relates to a method for synthesizing propranolol hydrochloride. In the present invention, epichlorohydrin and cresol are used as raw materials, acetonitrile is used as solvent, and the reaction is carried out under tetramethyl ammonium hydroxide to obtain an intermediate product, and then the intermediate product is prepared in metal salt Ni/α-Al 2 O 3 . Under the catalyst, react with isopropylamine to obtain propranolol, and finally obtain propranolol hydrochloride after salinization. The method can significantly improve the yield and purity of propranolol hydrochloride. |