http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113336646-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_785aef5376e92b3280401f44b8f6233d |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C67-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C67-28 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-78 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-28 |
| filingDate | 2021-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8642df3d2cc69d96ba5a4eefae9e3842 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f52dfb1f498eae1040b8a493a1276cc0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6e32ec6ef96fb305b8597e2437203ff8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2cc0d43c53f304100c6aa000bd3ae41d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_325969a1f300ac707e0a669aa23c7745 |
| publicationDate | 2021-09-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113336646-A |
| titleOfInvention | Preparation method of antitumor natural medicine melodienones and analogs thereof |
| abstract | The invention discloses a preparation method of anti-tumor natural medicine melodienones and analogs thereof. Benzoyl chloride (9) and cis-1,2-dimethylolethylene (10) obtain benzoic acid monoester product (8) under strong basic conditions, and benzoic acid monoester product (8) is oxidized to obtain unsaturated aldehyde (7), the unsaturated aldehyde (7) is treated with lithium methyl propiolate to give the precursor propargyl alcohol derivative (5), which undergoes a base-mediated redox isomerization reaction melodienone (1) and isomelodienone (3) are obtained. The present invention realizes the total synthesis of melodienone (1), homomelodienone (2), isomelodienone (3) and homoisosomelodienone (4) for the first time, and their structural analogs are used for subsequent structure-activity relationship, druggability development and production, and provide An efficient, reliable and economical preparation method. |
| priorityDate | 2021-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 54.