| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d9de52bba13e16028dffa8775e3f3f28 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-549
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7088
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7088
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P13-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-54 |
| filingDate |
2021-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0b6ca7dd98c6ed1a34022cd62e6c7a25
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3e0a035e2c140dfeb30339d719c02e8f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7f9bb75a5bf264131f1ad6ea21b65028
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aaec627fcb058129955882cf63ebb0bb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d3c1639e2724cb9e0254e991b7f4dcbd |
| publicationDate |
2021-09-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-113332444-A |
| titleOfInvention |
DNA nano device based on DNA origami and aC5a aptamer and preparation method and application thereof |
| abstract |
The invention provides a DNA nano device based on DNA origami and aC5a aptamer and a preparation method and application thereof. The DNA nano device is constructed by hybridizing rectangular DNA origami and aC5a aptamer. The DNA nanodevice based on the DNA origami and the aC5a aptamer is constructed to have controllable pharmacokinetic characteristics, ROS is eliminated in the I/R-stage one aiming at oxidative stress injury by utilizing the long retention time of aC5 a-rDNA in the kidney, and then inflammatory injury is effectively reduced in the I/R-stage two, so that multi-stage continuous combined treatment and sequential protection of AKI are realized. |
| priorityDate |
2021-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |