| abstract |
The invention discloses an extracellular Ezrin protein and its application. The present invention finds secretory Ezrin protein in bronchoalveolar secretion fluid and breast milk for the first time. Subsequently, high expression of this protein was also found in various luminal mucosa of the human body that communicate with the outside world, such as gastric mucosa, intestinal mucosa, gallbladder mucosa, placental chorion, and endometrium. Further experiments found that intracellular Ezrin could inhibit the proliferation of tumor cells, while secreted Ezrin did not affect the proliferation of cells. Secreted Ezrin can significantly inhibit the infiltration ability of leukocytes through the basement membrane, while intracellular Ezrin has almost no such ability. This result indicates that the extracellular secreted Ezrin has a strong immunosuppressive function, which is expected to become a new way of drug development for the treatment of immune-related diseases. |