http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113321675-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F7-0812 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F7-08 |
| filingDate | 2021-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113321675-B |
| titleOfInvention | Chiral 3-methylene indoline compound and preparation method thereof |
| abstract | The invention discloses a preparation method of a handled 3-methylene indoline compound, which directly takes alkynyl imine as a substrate to react with another part of terminal alkyne reagent in a catalytic system containing metal rhodium and chiral phosphine ligand to obtain chiral methylene terminal position containing extractionThe substituted indoline compound has the advantages of high yield, good enantioselectivity, mild reaction conditions, simple and easily obtained raw materials, wide substrate applicability, no need of adopting an N-protected substrate, and 100% atom economy. In addition, the invention also provides a chiral 3-methylene indoline compound shown in the formula (3), provides a methodological basis for the total synthesis of active molecules containing the core skeleton, and has important potential application value. |
| priorityDate | 2021-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 87.