http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113292593-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6fbb91e3f8cdf858527814216aa11142 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F7-1892 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F7-083 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F7-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F7-10 |
| filingDate | 2021-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_678de5324a9f8a921020eea9b3b94de1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_57051b2e6cd30724574e5d7ac8db445a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_49fbd070571d89f34bdce3eaa49f4472 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2704d508afab37de4600e29ca608ec47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c0638380ff3dc1869f2e0276af3a1153 |
| publicationDate | 2021-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113292593-A |
| titleOfInvention | A kind of alcohol derivative-directed activation method of aromatic ring remote hydrocarbons |
| abstract | The invention discloses a method for activating aromatic ring long-distance hydrocarbons guided by alcohol derivatives. Obtained and easily converted alcohol-derived oxime compounds are used as guiding groups to realize the regioselective carbon-hydrogen bond alkynylation of aromatic rings. The transformation is a neutral redox reaction, without the need to add a common chemical dose of monovalent silver salt as an oxidant. In addition, the transformation step is economical, has high regioselectivity, and realizes easy oxidation or elimination. Alcohol-promoted remote C-H alkynylation of aromatic rings via in situ generation of six-, seven-, and eight-membered ring palladium intermediates. More importantly, this transformation is also applied to the later modification of drug and pesticide molecules. Considering that alkynes are easily transformed synthons, this method can rapidly construct a drug molecule library, which is expected to be applied in the development of new drugs. |
| priorityDate | 2021-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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