http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113292535-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 |
| filingDate | 2021-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113292535-B |
| titleOfInvention | Method for preparing apaluamide intermediate and apaluamide |
| abstract | The invention relates to a method for preparing an apaluramine intermediate and apaluramine, which is a compound shown as a formula (5) The preparation method of the compound shown as the formula (5) for preparing the apaluramine as the intermediate comprises the step of leading the compound shown as the formula (3) A compound represented by the formula (4) And a step of reacting a thionation reagent to produce a compound represented by the formula (5); the thionation reagent is one or the combination of more of phenylthiocarbamate, N' -thiocarbonyldiimidazole and 1, 1-thiocarbonyldI-2 (1H) -pyridine. The inventor unexpectedly finds that under appropriate conditions, the 4- (1-carboxamide-cyclobutylamino) -2-fluoro-N-methyl-benzamide, the 5-amino-2-cyano-3-trifluoromethylpyridine and the phenyl thiocarbamate react in one step to obtain the apaluramide with a yield obviously higher than that of the prior art, and the purity of the apaluramide is maintained or even improved. Based on this finding, the present invention has been made and proposed through further studies. |
| priorityDate | 2021-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 90.