http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113292511-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-13 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C29-78 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C279-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C31-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C277-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-426 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-36 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C29-78 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-426 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C277-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C279-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C31-08 |
| filingDate | 2021-06-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-11-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-11-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113292511-B |
| titleOfInvention | Epalrestat-metformin salt ethanol water bisolvate and its preparation method and application |
| abstract | The present invention relates to an epalrestat-metformin salt ethanol water bisolvate and its preparation method and application; the molecular formula of the epalrestat-metformin salt bisolvate is C 21 H 32 N 6 O 5 S 2 , the molecular weight is 512.7; the crystallographic characteristics of the epalrestat-metformin salt bisolvate include: the bond length is a=8.4946 (4), b=8.9498 (5), c=18.9950 (10), and the bond angle is α= 81.488(4), β=80.867(5), γ=63.611(5), V=1272.3(1). The epalrestat-metformin salt ethanol-water bisolvate is crystalline, and its preparation method comprises: dissolving epalrestat and metformin in a mixed solvent of ethanol and water according to a molar ratio of 1:0.8-1:1.2; Reaction and crystallization at 15-60°C for 12-48 hours; the solid-liquid phase of the obtained product was separated and dried to obtain epalrestat-metformin salt ethanol-water bisolvate. The epalrestat-metformin salt ethanol-water bisolvate solves the problem of low solubility that limits the use of raw material drug epalrestat at the present stage, and at the same time, the method is simple to operate, the process is easy to control, and is suitable for industrialization. |
| priorityDate | 2021-06-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 39.