http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113284564-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16C10-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16C20-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16C60-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16C60-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16C20-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16C10-00 |
| filingDate | 2021-06-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113284564-B |
| titleOfInvention | A method for high-throughput screening of osteoinductive biomaterials doped with hydroxyapatite |
| abstract | The invention relates to the technical field of biological materials and computer software information, and provides a method for high-throughput screening of osteoinductive properties of hydroxyapatite biological materials. The purpose is to provide a general method that can quickly screen out a class of osteoinductive materials with excellent properties. The main scheme includes screening the hydroxyapatite doped hydroxyapatite with the most stable structure of the unit cell structure of the doped hydroxyapatite material, and performing the crystal plane expansion in the vector directions of different crystal arrangements to obtain crystal plane structures with different morphologies. The high-throughput docking between the material structure of bone growth factor and biomolecules can screen out the adsorption complex configuration; for the adsorption complex configuration, through high-throughput molecular dynamics simulation, the crystal face structure of doped hydroxyapatite and the bone structure are screened out. The optimal adsorption conformation of growth factor; the crystal structure of the best osteoinductive doped hydroxyapatite material and the favorable bone growth factor were obtained by integrating and analyzing the results of the optimal adsorption conformation. |
| priorityDate | 2021-06-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 66.