| abstract |
The invention relates to the field of tumor targeted therapy, in particular to a regulator that inhibits the ubiquitination of p53 protein and its application. The regulator is a substance that downregulates the RNF187 gene or inhibits the expression of the RNF187 protein. The present invention thus provides a therapeutic application of inhibiting p53 protein ubiquitination through RNF187 protein inhibitor, thereby promoting p53 signal transduction, inducing cell cycle arrest and apoptosis, and treating cancer, especially luminal breast cancer. |