http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113264845-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J19-0046 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01F25-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01F33-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01F33-811 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J19-0093 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01F33-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01F25-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01F33-81 |
| filingDate | 2021-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113264845-B |
| titleOfInvention | Method for continuously preparing chloramphenicol by using micro-reaction system |
| abstract | The invention belongs to the technical field of pharmaceutical engineering, and particularly relates to a method for continuously preparing chloramphenicol by using a micro-reaction system. Respectively and simultaneously pumping an organic solution of raw materials (1R, 2R) -2-amino-1- (4-aminophenyl) propane-1, 3-diol and an organic solution of methyl dichloroacetate into a micro reaction system of a first micro mixer and a first micro channel reactor which are communicated with each other for continuous amidation reaction; and adding acetone, water and a buffer solution into the effluent mixed solution, and then respectively and simultaneously pumping the mixed solution and the aqueous solution of the oxone complex salt into a micro-reaction system of a second micro-mixer and a second micro-channel reactor which are communicated with each other for carrying out continuous oxidation reaction. Finally, the chloramphenicol product is obtained through the processes of quenching, extraction and the like. The method has the advantages of short reaction time, yield of the product chloramphenicol of more than 90 percent, convenient operation, continuous and controllable property, no amplification effect, high process efficiency and good industrial application prospect. |
| priorityDate | 2021-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 68.