http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113262230-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-76 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B30-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B25-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-506 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16B25-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16B30-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N21-76 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 |
| filingDate | 2021-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113262230-B |
| titleOfInvention | Targeted pig streptococcus serine and threonine protein kinase inhibitor and application thereof |
| abstract | The invention belongs to the technical field of drug target screening, and particularly relates to a targeted swine streptococcal serine and threonine protein kinase inhibitor and application thereof. Based on the phenotype and chemiluminescence technology of growth defects of streptococcus suis STK mutants in a CDM culture medium, possible STK inhibitors are primarily screened out according to the growth conditions of streptococcus suis SC19 in the CDM culture medium during small molecule treatment, and the STK-targeted streptococcus suis inhibitors are further screened out through autophosphorylation enzyme activity reaction. The screening of the drug library of the invention identifies 2 compounds, namely inhibitors APY29 and AT9283, which have the inhibition effect on the swine streptococcus serine threonine protein kinase STK and the swine streptococcus. |
| priorityDate | 2021-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 50.