Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cc2f033cf787c3ba45770fe96b5700a2 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-565 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5052 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-56972 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-566 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6854 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57484 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2803 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 |
filingDate |
2019-12-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4c2aca394e8c8d70555d2c583435f960 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dbfe084165febdc99071886b1ebb02be |
publicationDate |
2021-08-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
CN-113260861-A |
titleOfInvention |
Methods for selecting biobinding molecules |
abstract |
The present invention relates to the field of preparation, identification and selection of biological binding molecules, such as, in particular, antibodies or fragments thereof that selectively bind to somatically hypermutated B cell receptors or B cell receptor complexes. The method is used to select a biological binding molecule that specifically binds to a B cell receptor having a hypermutated region as a target receptor, but does not bind to a B cell receptor that does not have a hypermutated region, and The method is carried out within the context of a cell-based system using immature B cells that are in progenitor/pre-stage and have a "triple knockout" of RAG2 or RAG1, Lambda5 and SLP65 genes . |
priorityDate |
2018-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |