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publicationDate 2021-08-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-113260710-A
titleOfInvention Compositions, systems, devices and methods for validating microbiome sequence processing and differential abundance analysis with multiple custom blend mixtures
abstract Compositions, systems, and methods for generating and using combined internal standard blend mixtures including template spikes. The compositions, systems and methods described herein involve using the internal standard spike mixture to evaluate a set of workflows for differential abundance analysis of samples containing target nucleic acid sequence variants of interest. The compositions, systems and methods described herein relate to the use of the internal blending mixture to validate results obtained from differential abundance analysis of samples containing target nucleic acid sequence variants of interest, where the variants may be highly predictable The relative abundance of variable levels.
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