http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113248524-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4fb38ebd40c70e97cc5f1519c6699162 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D519-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D519-00 |
| filingDate | 2021-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dbffd0ac6ded257c10fe30b42451fd78 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0ba05777e31c3c5b7e5b717bfebfd86f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_061055c3c95bf118076c9d46336c7ae6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1e01e0e53dc1f39b9d5140d9272c05bb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ddf86921d3fc3cf1d5d94d75efc63353 |
| publicationDate | 2021-08-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113248524-A |
| titleOfInvention | A kind of bisindole alkaloid compound and its synthetic method and use |
| abstract | The invention discloses a bisindole alkaloid compound and a synthesis method and application thereof. The compound has the structure shown in formula I, wherein: R 1 is independently selected from C 1 -C 4 alkoxy or hydrogen; R 1 is alkoxy, and n is 1 or 2; R 2 is independently selected from C 1 -C 4 alkyl or hydrogen; R 3 is independently selected from C 1 -C 4 alkoxycarbonyl or hydrogen; R 4 is hydrogen; R 5 is independently selected from C 1 -C 4 alkyl or C 1 -C 4 hydroxyalkyl; R 6 is independently selected from carbonyl, hydroxyl or hydrogen. The bisindole alkaloid compounds of the present invention can selectively relax the pulmonary artery, inhibit the proliferation of pulmonary artery endothelial cells and vascular smooth muscle cells, reduce the right ventricular diastolic pressure and inhibit the right ventricular hypertrophy in mice with pulmonary hypertension. The bisindole alkaloid compound of the present invention can resist drug addiction in a dose-dependent manner, has a different chemical structure type from the existing anti-addictive drugs, and is expected to be developed into a new type of anti-addictive drugs. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022217859-A1 |
| priorityDate | 2021-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 174.