http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113248397-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2603-46 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C303-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C303-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C309-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-12 |
| filingDate | 2021-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-11-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-11-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113248397-B |
| titleOfInvention | A kind of preparation method of doxycycline hydrochloride |
| abstract | The invention provides a preparation method of doxycycline hydrochloride, which comprises the steps of preparing a reducing agent magnesium borohydride solution, preparing 11-α chlorodeoxyoxytetracycline, and preparing sulfosalicylic acid for doxycycline hydrochloride doxycycline hydrochloride is prepared; the present invention avoids the use of heterogeneous catalysts containing precious metals, reduces production costs, adopts chemical methods, and uses borohydride to achieve reduction and dechlorination reactions, and improves the reaction selectivity by about 2% to 3% %, no longer use hydrogen as a hydrogen source to reduce the safety risk of dechlorination and reduction reaction process, 11α-chloromethyoxytetracycline is a raw material, and the sulfo group of doxycycline hydrochloride prepared through reduction and dechlorination Salicylate, the total yield is 90-92.2%. |
| priorityDate | 2021-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 56.