| abstract |
The invention discloses the application of a STRAP inhibitor in the preparation of a product for treating invasive breast cancer, and relates to the technical field of biomedicine. The invention finds that STRAP plays an important role in the occurrence, development and metastasis of invasive breast cancer, and STRAP can Enriched by KTN1 antibody, STRAP cooperates with KTN1 to promote the phosphorylation of NF-κB/p65, leading to the transcriptional activation of CXCL8, thereby promoting the occurrence, development and metastasis of triple-negative breast cancer. Inhibiting the expression of STRAP can inhibit the migration and invasion of breast cancer cells, providing a new approach for the treatment of invasive breast cancer. |