| abstract |
The invention belongs to the technical field of traditional Chinese medicine applications, and in particular relates to the application of alcohol extracts of Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Polygoni in the preparation of medicaments for treating or protecting and regulating liver fibrosis diseases; using methanol to extract Rhizoma Rhizoma Rhizoma Rhizoma officinalis, heating and refluxing, adding methanol for reflux extraction again, and combining The extract was filtered, and the solvent was recovered under reduced pressure, and then freeze-dried to obtain it; by establishing a mouse model of liver fibrosis, the alcohol extract of Rhizoma Rhizoma was used to administer high, medium and low doses of different doses to the mouse model of liver fibrosis. The study found that The alcohol extract of Rhizoma Rhizoma has a certain protective effect on CCl 4 -induced liver fibrosis in mice, which is related to inhibiting oxidative stress response, reducing the level of inflammatory factors, regulating the expression of TGF-β1/Smad signaling pathway-related proteins and inhibiting HSC activation. , decreased α-SMA expression and decreased collagen synthesis. |