| abstract |
The invention relates to a self-assembling polypeptide, and the sequence structure of the polypeptide is: Fmoc-LFKFFK-NH 2 . The invention also relates to a polypeptide hydrogel and its preparation method and application. The beneficial effects of the present invention are as follows: the polypeptide hydrogel prepared by the present invention has good cell compatibility and blood compatibility, and can promote the proliferation, adhesion and extension of L-929 cells; It can migrate and promote the formation of new blood vessels through the VEGFA and HIF-1α signaling pathways; it can kill gram-positive bacteria (MRSA) and gram-negative bacteria (Pseudomonas aeruginosa) through cell membrane destruction; After MRSA-infected wounds in mice, it can effectively kill MRSA in the infected wounds, significantly promote wound healing and the formation of new blood vessels at the wounds, and will not be toxic to other tissues in mice. |