http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113230403-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a53dfce5662cf421ac5659668e3649f4 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2020-05-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_937d9b79923acacfad522cefaf44a7bc |
| publicationDate | 2021-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113230403-A |
| titleOfInvention | Application of p38β MAPK target in drug development of uterine leiomyoma |
| abstract | The invention discloses the application of p38βMAPK target point in drug development of uterine leiomyoma. The present invention can inhibit activin A-induced extracellular matrix deposition and cell proliferation in human uterine leiomyoma cells by specifically negatively regulating p38βMAPK through transcription and gene technology, and prevent activin A-induced human/mouse uterine smooth muscle cells from developing The phenotypic transformation and functional transformation of myofibroblasts revealed for the first time the key role of p38βMAPK in the occurrence and development of uterine leiomyomas. The present invention breaks through the limitation of existing drugs that only regulate hormones and hormone receptors, and finds a new way to explore p38βMAPK, a non-hormone and hormone receptor-regulated target for preventing and treating uterine leiomyoma, and strongly supports the development of specific inhibition of p38βMAPK. The drug expressing or exerting activity can solve the problem of large side effects of existing uterine leiomyoma drugs. |
| priorityDate | 2020-05-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 142.