| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3c96af599b7d29b6715a68a0b4c224a1 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-54
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-70
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2770-20034 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-12 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-215
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-14 |
| filingDate |
2021-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_289bccecee183fd6371957b17bcc7fa9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_351a9b985f1fc38336cfd74ef33e70e1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ac89daabb91b2df1d3f5fc0584f280c9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_197e033ff6e5fe8f3e9bb3a8028e6b0c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0733218f54bc4482e095e2e0cb01df24 |
| publicationDate |
2021-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-113230395-A |
| titleOfInvention |
A kind of betacoronavirus antigen, betacoronavirus dual vaccine and preparation method and application thereof |
| abstract |
The invention relates to a betacoronavirus antigen, a betacoronavirus dual vaccine and a preparation method and application thereof. The amino acid sequence of described betacoronavirus antigen includes according to the sequence from N-terminus to C-terminus: amino acid sequence arranged according to (A-B)-(A'-B') pattern or (A-B)-C-(A' -B') amino acid sequence arranged in a pattern, wherein: A-B represents the partial amino acid sequence or the whole amino acid sequence of the receptor binding region of the surface spike protein from beta coronavirus, and A'-B' represents the amino acid sequence from another beta coronavirus The partial amino acid sequence or the entire amino acid sequence of the receptor binding region of the surface spike protein of the coronavirus, C represents the connecting amino acid sequence, and the betacoronavirus antigen is a single-chain heterodimer structure. A betacoronavirus doublet vaccine was obtained using this betacoronavirus antigen, which stimulated a strong antibody response in mice. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115975042-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115678906-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115678906-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023056911-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023079528-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023025257-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114736304-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114740199-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113912708-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113999938-A |
| priorityDate |
2020-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |