| abstract |
The present invention includes compounds of formula (I) wherein the groups R1 to R4, R7 , A , D, E, F, V, W, X, Y, n, r and q are as defined in claim 1, Its use as an inhibitor of the MDM2-p53 interaction, a pharmaceutical composition comprising such a compound, its use as a medicament, especially as a medicament for the treatment and/or prevention of neoplastic diseases, and synthetic intermediates. |