http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113214223-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2531-31 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2531-0213 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2531-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2531-842 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2231-4283 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J31-1691 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-412 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J31-2239 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-41 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J31-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C57-15 |
| filingDate | 2021-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113214223-B |
| titleOfInvention | Preparation method of Voranolan fumarate impurity |
| abstract | The invention relates to a preparation method of Vonopalagen fumarate impurity, metal-organic skeleton coordination compound formed by metal iron, aluminum or chromium and 1,3, 5-tri (4-carboxyl phenyl) benzene is selected as catalyst, compound II and dimethyl carbonate carry out methylation reaction under the action of acid-binding agent to obtain intermediate product, compared with common molecular sieve and phase transfer catalyst in methylation reaction process, the catalyst provided by the invention has high selectivity, lower reaction temperature, high yield and purity of intermediate product, the yield reaches more than 97%, and the purity reaches 95%; the product can be salified with fumaric acid through simple filtration to obtain a target product, the purity and the yield of the target product are high, the yield reaches over 80 percent, the purity reaches 99 percent, the post-treatment is simple, and the method is suitable for industrial production. |
| priorityDate | 2021-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 77.