| abstract |
The present invention provides a kind of N-(2-(4-benzylpiperidin-1-yl)propyl)-N-phenylpropionamide, its pharmaceutical composition and application thereof, which are used for preventing or treating pain class disease. In the formalin-induced pain model, its ED 50 value was lower than that of the positive drug pregabalin; in the acetic acid writhing model, the results showed that the S-configuration N-(2-(4-benzylpiperidine- The ED50 of 1-yl)propyl)-N-phenylpropionamide is lower than that of R-configuration N-(2-(4-benzylpiperidin-1-yl)propyl)-N-phenylpropionamide , and better than the racemate N-(2-(4-benzylpiperidin-1-yl)propyl)-N-phenylpropionamide, and has better analgesic activity. |