abstract |
The invention discloses a cannabidiol self-nanoemulsion buccal membrane preparation as well as a preparation method and application thereof. The biological adhesive film comprises a backing film and a biological adhesive film layer adhered on the backing film; the biological adhesion film layer is formed by dispersing cannabidiol in a self-nanoemulsion system, adsorbing the cannabidiol by a solid carrier and then dispersing the cannabidiol in a film-forming polymer, wherein the self-nanoemulsion system comprises an oil phase, a surfactant and a cosurfactant. The cannabidiol self-nanoemulsion membrane preparation enables the cannabidiol to be in a supersaturated dissolution state in an oil phase, the solubility of the cannabidiol in a system is increased, the nano-scale liquid drops formed from the nanoemulsion promote the permeation and absorption of the cannabidiol in buccal mucosa, the onset time of the medicine is shortened, and the bioavailability of the medicine is improved. The cannabidiol self-nanoemulsion buccal membrane preparation can be applied to aspects of epilepsy resistance, pain relief, mental disorder (such as schizophrenia, schizoaffective disorder and delusional disorder), anxiety resistance, depression resistance and the like. |