http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113201048-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2c6d84b93df26355a38c11587e8b6077 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-001 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K9-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-16 |
| filingDate | 2015-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_311769519b7755a13d03e29e32715af3 |
| publicationDate | 2021-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113201048-A |
| titleOfInvention | Multi-target compound with anticoagulant and antiplatelet activity, preparation method and use |
| abstract | The present invention relates to a general formula and a physiologically acceptable salt thereof: A-L-B-L'-C, wherein A and B are binding sites with thrombin, and C is a receptor for platelet GPIIb/IIIa The binding site, L is the first linking group, and L' is the second linking group. The present invention also relates to the preparation method of the compound and its use. The invention provides an anticoagulant and antiplatelet GPIIb/IIIa receptor multi-target compound, which has good in vitro human thrombin inhibitory activity, in vitro platelet GPIIb/IIIa receptor inhibitory effect and in vitro/in vivo antiplatelet activity Aggregation, in vivo anticoagulant and antithrombotic effects, clinically used for the prevention and treatment of peripheral arterial thrombosis and arteriovenous bypass thrombosis, treatment of acute coronary syndrome (ACS) or thrombosis in percutaneous coronary intervention (PCI) formation, and prevention and treatment of ischemic stroke. |
| priorityDate | 2015-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 188.