http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113201047-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-0821 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-097 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 |
| filingDate | 2021-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-11-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-11-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113201047-B |
| titleOfInvention | A walnut meal anti-inflammatory peptide WPL and its application |
| abstract | The invention belongs to the technical field of food deep processing, and in particular relates to an anti-inflammatory peptide isolated from an enzymatic hydrolysis product of walnut dregs and an application thereof. The amino acid sequence from the C-terminal to the N-terminal of the anti-inflammatory peptide is: Trp-Pro-Leu, referred to as WPL. The present invention prepares anti-inflammatory polypeptide from walnut dregs by enzymatic hydrolysis, purifies by ultrafiltration and Sephadex gel chromatography, identifies the polypeptide sequence by LC-MS/MS, and uses molecular docking technology to screen anti-inflammatory active fragments for scoring Higher peptides were artificially synthesized and their anti-inflammatory activity was verified. It was found that WPL has anti-inflammatory activity and has different degrees of inhibition on the production of three inflammatory mediators (NO, TNF-α, IL-1β). Molecular docking results showed that WPL and iNOS were mainly connected by π-π stacking, alkyl bond, π-alkyl bond and hydrogen bond. |
| priorityDate | 2021-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 188.