http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113200841-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-584 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C59-64 |
| filingDate | 2021-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113200841-B |
| titleOfInvention | Novel process for synthesizing racemic naproxen based on Heck coupling |
| abstract | The invention discloses a novel process for synthesizing racemic naproxen based on Heck coupling, which comprises the following steps: (1) performing Heck coupling reaction on 2-X substituted-6-methoxynaphthalene and crotonamide in an aprotic organic solvent under the action of a palladium catalyst and alkali to generate 3- (6-methoxynaphthyl-2-) -crotonamide; (2) carrying out Hofmann degradation reaction on 3- (6-methoxy naphthyl-2-) -crotonamide in an alkaline solution of hypochlorite to generate 2- (6-methoxy naphthyl-2-) -propionaldehyde, directly adding chlorite without separation into the 2- (6-methoxy naphthyl-2-) -propionaldehyde, and oxidizing at room temperature to obtain the racemic naproxen. The process of the invention does not need to prepare highly active Grignard reagent, does not need strict anhydrous condition, has higher conversion rate and is easy to purify the product. |
| priorityDate | 2021-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 94.