abstract |
The invention belongs to the field of pharmaceutical preparations, and in particular relates to a compound comfrey microemulsion temperature-sensitive in-situ gel and a preparation method and application thereof. The compound comfrey microemulsion temperature-sensitive in-situ gel component includes compound comfrey drug dry extract, oil phase, emulsifier, co-emulsifier and temperature-sensitive gel matrix; among them, isopropyl myristate, polyoxyethylene (35 ) castor oil and glycerol as oil phase, emulsifier and co-emulsifier, respectively; Poloxamer P407 and Poloxamer P188 are preferred as thermosensitive gel bases. Compound Lithospermum microemulsion thermosensitive in situ gel is liquid at room temperature, and it is administered vaginally in liquid state. Due to the change of temperature, the viscosity of the gel increases rapidly at body temperature, and then turns into a semi-solid state and closes with the vaginal mucosa. Combined, the residence time of the drug can be improved and the curative effect can be better exerted. Active ingredients have high solubility in microemulsion formulation excipients, which can effectively reduce the amount of excipients added, thereby reducing the irritation of the preparation. |