| abstract |
The invention discloses a polymer vesicle nano-STING agonist and a preparation method and application thereof. The STING agonist solution is added to the buffer solution, and then the polymer solution is added, and the polymer vesicle nano-STING agonist is obtained by dialysis after stirring. The polymer vesicle nano-STING agonist of the present invention is composed of polymer vesicles loaded with STING agonists; the polymer vesicles have small particle size, can efficiently load STING agonists, and have high biological safety, drug loading stability and Reduction-responsive, the first time vesicles have been loaded with STING agonists in combination with radiation for the treatment of malignant melanoma, the nanoscale properties of polymeric vesicles enhance antigen-presenting cell (APC) uptake of STING agonists, prolonging The retention of STING at the tumor site greatly enhanced the immune activity of STING agonists and enhanced the activation of the STING pathway. |