| abstract |
The present invention relates to human Lefty A protein variants with improved productivity and stability, fusion proteins comprising the protein variants, and compositions for preventing and/or treating neuromuscular diseases, the compositions comprising the protein variants or fusion protein. According to the present invention, a human Lefty A protein variant and a fusion protein comprising the variant are constructed, which have better stability than the naturally-occurring human Lefty A protein, and are therefore highly expressed in animal cells and can be High volume production. In addition, administration of the constructed human Lefty A protein variant or fusion protein restores neural and motor function in animal models of peripheral neuropathy. Therefore, the use of human Lefty A protein variants or fusion proteins can effectively prevent or treat various neurological and muscle diseases. |