| abstract |
The present invention relates to an oral pharmaceutical composition containing a cholinergic agent, in particular a natural plant alkaloid selected from the group consisting of sabain, anabasine, genistein, galantamine or acceptable salts thereof, which Available in tablet and capsule form. The excipients of the developed oral composition include cellulose powder, calcium sulfate, colloidal silicon dioxide and magnesium stearate, and the total content of the cellulose powder and calcium sulfate dihydrate is 64.5 to 97.5% and at least 90% by mass of the dosage form The alkaloid particles are less than or equal to 100 μm. The oral composition also contains at least one biologically active amino acid selected from the group consisting of: L-carnitine, tryptophan, or a combination thereof. The oral composition of the present invention achieves uniform distribution of the active substance in the composition, and stability of the composition due to the inclusion of selected excipients to minimize reactions with alkaloids to form a pharmaceutical composition allowing Qualitative and quantitative related substances. The compositions according to the present invention can be used in the treatment of dependence and addiction to nicotine, tobacco products and alcohol. |