http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113185489-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D317-30 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D317-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-13 |
| filingDate | 2021-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113185489-B |
| titleOfInvention | Methods for the synthesis of acid hydrolyzed compounds and their methods for solid-phase coupled glycoproteins, solid-phase modified derivatization and enrichment of glycopeptides |
| abstract | The invention discloses a method for synthesizing an acid hydrolyzed compound and a method for solid-phase coupling glycoprotein, solid-phase modification derivatization and enrichment of glycopeptide. Compound 6, then the compound is subjected to reductive amination reaction with silica gel with an amino group to obtain compound 7 covalently bound to the silica gel, and then the Schiff-base reaction is used to covalently bind malondialdehyde and compound 7 to obtain compound 8, which is then combined with the compound 8. The glycoprotein or glycopeptide is covalently bound to form 9, the treated glycopeptide is incubated with an acidic solution, and the labeled glycopeptide 10 is obtained by initial hydrolysis and elution with dioxolane at room temperature. This method is of great significance for studying the changes of sialoglycoprotein or glycopeptide in various diseases. |
| priorityDate | 2021-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 46.