| abstract |
The present invention provides a multilayer polymer film for implantation at a surgical site in a subject for controlled or sustained release of an active agent, the film comprising: a top layer, a bottom layer, and a layer between the top layer and the bottom layer the middle layer in between; the top and bottom layers are both formed from a biodegradable polymer and a release agent comprising one or more small biocompatible hydrophilic molecules that, when the membrane is in contact with water The release agent is dissolved or detached from the surrounding polymer at the time of surgery or under the physiological conditions of the surgical site; the intermediate layer comprises the biodegradable polymer, the release agent and the active agent, the active agent 40-80 wt % of the middle layer; the top and bottom layers do not include an active agent at least before the membrane is implanted at the surgical site, and the membrane is used for 3-3 after implantation at the surgical site The active agent is released at the surgical site within 14 days. |