| abstract |
The present invention relates to systems and methods for autofocusing in imaging mass spectrometry. The present invention provides an improvement over current IMS and IMG devices and methods by including multiple apertures, such as multiple apertures in a two-dimensional arrangement, in an autofocus system. Since the use of multiple apertures in an autofocus system provides redundancy in the event of a failed focus on the sample measured from illuminating radiation passing through one or more apertures, the number of unsuccessful autofocus attempts is reduced. |