| abstract |
The present invention relates to the fields of immunology and autoimmunity. More specifically, the present invention provides methods and compositions for the production and use of antibodies to the pancreatic zinc transporter ZnT8. The present invention also provides an isolated antibody or antigen-binding fragment thereof that specifically binds ZnT8, the isolated antibody or antigen-binding fragment thereof comprising a VH comprising in SEQ ID NOs: 2, 12, 22, 32, 42 and 52 one of the amino acid sequences shown. In alternative embodiments, the isolated antibody or antigen-binding fragment thereof that specifically binds ZnT8 comprises a VL comprising one of the amino acid sequences set forth in SEQ ID NOs: 7, 17, 27, 37, 47 and 57. |