| abstract |
Some aspects of the present disclosure relate to complexes comprising a muscle targeting agent covalently linked to a molecular cargo. In some embodiments, the muscle targeting agent specifically binds to an internalizing cell surface receptor on a muscle cell. In some embodiments, the molecular cargo inhibits the activity of ACVR1. In some embodiments, the molecular cargo is an oligonucleotide, such as an antisense oligonucleotide or an RNAi oligonucleotide. |