http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113150073-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 |
| filingDate | 2020-01-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113150073-B |
| titleOfInvention | Gram-negative bacterium octa-type secretion system inhibitor and application thereof |
| abstract | The invention provides a gram-negative bacterium type VIII secretion system inhibitor and application thereof. The inhibitor is a substance which is targeted to bind a secretory channel protein CsgG of a gram-negative bacterium octamer secretion system, can limit or close a secretory channel of the bacterium octamer secretion system and can compete with CsgF to bind the CsgG. The invention exemplarily shows a polypeptide inhibitor of an escherichia coli eight-type secretion system, and the amino acid sequence of the polypeptide inhibitor is shown as SEQ ID NO. 1. The bacterial octamer secretion system is inhibited by altering the environment of the secretory pathway and by competitively binding the secretory channel protein (CsgG) with the native protein component (CsgF), thereby inhibiting the production of Curli. The invention is expected to be popularized and applied to the inhibition of other similar channel proteins. |
| priorityDate | 2020-01-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 43.