http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113143884-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-55505 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-513 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0052 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-39 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-39 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-51 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2021-04-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113143884-B |
| titleOfInvention | A kind of lignin nanoparticles for photothermal-immunotherapy and preparation method thereof |
| abstract | The present invention provides a lignin nanoparticle for photothermal-immunotherapy and a preparation method thereof: (1) uniformly dispersing lignosulfonate and indocyanine green in pure water to obtain a mixed solution; (2) ) under normal temperature stirring conditions, the aluminum chloride solution is added dropwise to the mixed solution, and then the reaction is protected from light; (3) solid-liquid separation is obtained after the reaction is completed, and LS-Al-ICG nanoparticles are obtained. The LS-Al-ICG nanoparticles provided by the invention have uniform particle size, good dispersibility and stability, and have good photothermal conversion effect in vitro. Appropriate concentration of LS-Al-ICG nanoparticles solution has good biosafety, combined with 808nm laser irradiation can kill more than 70% of tumor cells, LS-Al-ICG nanoparticles have excellent anti-tumor effect in vitro, and can Stimulate immune response. The lignin nanoparticles prepared by the invention can be used for preparing antitumor drugs in photothermal-immunotherapy. |
| priorityDate | 2021-04-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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