| abstract |
The present disclosure relates to fused pyrimidine derivatives, their preparation methods and their applications in medicine. Specifically, the present disclosure relates to a fused pyrimidine derivative represented by general formula (I), a preparation method thereof, a pharmaceutical composition containing the derivative, and its use as a therapeutic agent, especially as an inhibitor of ATR kinase Use of the agent and in the manufacture of a medicament for the treatment or prevention of hyperproliferative diseases. |