http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113135838-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C241-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C249-16 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C243-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C241-04 |
| filingDate | 2021-04-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113135838-B |
| titleOfInvention | A kind of method of continuous flow synthesis benserazide hydrochloride |
| abstract | The invention belongs to the technical field of drug preparation, and in particular relates to a preparation method for continuous flow synthesis of benserazide hydrochloride. The method includes the following steps: S1: transporting the ethanol solution of the starting material hydrazide hydrochloride to the heat exchanger, and then entering the reactor, and also transporting the ethanol solution of trihydroxybenzaldehyde to the reactor, and reacting to obtain hydrochloric acid The ethanol suspension of benzyl hydrazone; S2: the ethanol suspension of benzyl hydrazone hydrochloride enters another reactor, and hydrogen is passed into the reactor at the same time; S3: after the reaction solution is continuously collected, the organic phase is concentrated under reduced pressure, Ethanol was recovered to obtain crude product. The benserazide hydrochloride synthesized by the continuous flow reaction method of the present invention has a maximum yield of about 88%, and a maximum purity of about 99.7%, which reduces the impurity B generated by the excessive reaction, and the content of the impurity B is only 0.23%, Far below the 0.5% required by the Pharmacopoeia. In addition, the method of the present invention is simple to operate, easy to industrialize production, and at the same time occupies a small area and has low operation cost. |
| priorityDate | 2021-04-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 40.