http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113134090-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-39558 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4985 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4985 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2021-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113134090-B |
| titleOfInvention | Anti-tumor medicine composition |
| abstract | The invention discloses a pharmaceutical composition consisting of a deubiquitinase USP8 inhibitor and a PD-1/PD-L1 antibody. The invention discloses that deubiquitinase USP8 can regulate the abundance of PD-L1 protein in various tumor cells, and the expression of PD-L1 can be obviously improved by using an inhibitor of USP8 or knocking out USP8 in the tumor cells, and the expression of an antigen presenting gene is concomitantly regulated up. In a mouse tumor model, the combined use can significantly inhibit tumor growth and improve survival of mice compared to the use of either the USP8 inhibitor or the PD-1/PD-L1 antibody alone. Therefore, the invention not only discloses a molecular mechanism of USP8 for regulating the expression of PD-L1 and antigen presenting genes, but also provides that the combination of a USP8 inhibitor and a PD-1/PD-L1 antibody can obviously improve the clinical curative effect on tumor patients. |
| priorityDate | 2021-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 92.