http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113134084-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0052 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6925 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-225 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y5-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-69 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B82Y5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2021-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-12-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-12-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113134084-B |
| titleOfInvention | Glutathione Stimulation Induced Aggregation Type Composite Gold Nanoparticles and Its Preparation |
| abstract | The invention discloses a glutathione stimulation-induced aggregation composite gold nanoparticle and its preparation. The composite nanoparticle consists of gold nanoparticle, polydopamine coating and grafted methoxy-terminated cystamine in sequence from the inside to the outside. Aminopolyethylene glycol. The size of the composite particles is small, and the coated PDA coating and long-chain polyethylene glycol make it have good biocompatibility, which also reduces the phagocytosis of the reticuloendothelial system and increases its blood residence time. After reaching the tumor cells, the high concentration of reduced glutathione in the tumor microenvironment will reduce the disulfide bonds in the composite nanoparticles to sulfhydryl breaks, and the nanoparticles will remove the polyethylene glycol After breaking the original electrostatic balance between the particles, the LSPR of the particles is transferred to the near-infrared light region after the formation of large aggregates, enhancing its ability to absorb near-infrared light, so that it can be used for photoacoustic imaging and photothermal therapy of tumors . |
| priorityDate | 2021-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 53.