| abstract |
The invention belongs to the field of pharmaceutical preparations, and in particular relates to a CaO 2 /Fe 3 O 4 @OA nanocomposite and a preparation method and application thereof. The invention provides a CaO 2 /Fe 3 O 4 @OA nanocomposite, which coats OA on the surface of CaO 2 /Fe 3 O 4 composite nano-particles to improve the stability of CaO 2 in the process of circulation in vivo and reduce its toxicity. At the same time, the pH - sensitive waterproof material OA was used to improve the stability of CaO2 , overcoming the high reactivity of CaO2 with water, and the CaO2 / Fe3O4 @OA nanocomposite was constructed in a simple, convenient and fast way It can stabilize the CaO 2 /Fe 3 O 4 system when it circulates in the body and reach the tumor site, release the drug in the weakly acidic environment of the tumor and generate high levels of hydroxyl radicals (∙OH), thereby effectively killing tumor cells, Inhibit tumor growth. The preparation method is simple, the conditions are mild and the cost is low. It has good prospects for clinical translation. |