http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113121648-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-08 |
| filingDate | 2015-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113121648-B |
| titleOfInvention | N-methyl cyclic pentapeptide compound and synthesis method and application thereof |
| abstract | The invention discloses an N-methyl cyclic pentapeptide compound and a synthesis method and application thereof, wherein the N-methyl cyclic pentapeptide compound has a structure shown in a general formula (I): wherein: ar is a fused ring aryl or substituted fused ring aryl; R1-R4 are each independently isopropyl, isobutyl, methyl; r '1-R' 5 are independent hydrogen and methyl respectively. The N-methyl cyclic pentapeptide compound has good anti-tumor activity, particularly has higher activity on resisting gastric cancer cells, cervical cancer cells, renal clear cancer cells or pancreatic cancer cells, and has the action way of inducing caspase-3 to play a role in apoptosis of tumor cells through caspase-9. These cyclic peptides exhibit good enzyme stability and have a long half-life. |
| priorityDate | 2015-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 85.