| abstract |
The invention belongs to the field of drug synthesis and discloses a method for synthesizing clindamycin phosphate. The present invention is tert-butyl(2-chloro-1-(3,4,5-trihydroxy-6-(methylthio)tetrahydro-2H-pyran-2-yl)propyl)carbamate It is first chlorinated with phosphorus trichloride, then esterified with phosphorus oxychloride, and finally subjected to a condensation reaction with 1-methyl-4-propylpyrrolidine-2-carboxylic acid to obtain clindamycin phosphate. The method for synthesizing clindamycin phosphate provided by the invention uses molecules with smaller molecular weights as raw materials, which reduces the difficulty of purifying the intermediate, improves the recovery rate of the intermediate and reduces the production cost. The invention also provides an application of the method for synthesizing clindamycin phosphate. The method is used for synthesizing clindamycin phosphate, and the obtained clindamycin phosphate is used for preparing clindamycin phosphate injection . |